A lot of acid, sulfate, heavy metal and other hazardous substance have been released into environment during the process of the exploitation of sulfide or sulfide bearing deposit such as middle, high sulfur coal, which led to secondary geochemical anomalies and environment problem. The discharge amount of sulfide will reach to 39.1 million tons inside the Mainland China in 2010. Therefore, people are paying more attention to the behavior of sulfide minerals under epigenetic condition. The oxidation rate of sulfide minerals were controlled by the properties of physical chemistry such as composition, structure and surface properties of sulfide minerals, and the medium condition such as dissolved oxygen, Fe 3+ concentration, pH, Eh, temperature and microorganism. On the basis of reviewing recent literature, this paper reviews the experimental method of reaction kinetics of sulfide minerals oxidation, experimental condition and factors considered, reaction mechanism, reaction products and reaction rate. Finally, the authors point out that future study should focus on oxidation reaction rate of early stage, medium products, mutual effect of multifarious factors on reaction process and the mechanism of oxidation reaction kinetics of sulfide minerals on molecules level.