Deserts in the northern monsoon margin of China are extremely sensitive to climate change and are, therefore, ideal for studying climate and environmental change. Specifically, their environmental evolution is scientifically important for understanding the regional responses to global change. Studies have shown that the environmental evolution of deserts in the monsoonal fringe, since the Last Glacial Maximum, is mainly controlled by variations in the Asian summer monsoon intensity and precipitation. However, in the Kobq Desert, there is a mismatch between the simultaneous increase in aeolian sand activity and monsoonal precipitation during the early Holocene. Taking the WK profile at the northern edge as an example, we applied multi-proxy analysis of the chronological sequence of aeolian deposition. The results indicate that the effective moisture variation generally follows the “monsoon” pattern：relatively low (28~26 ka)—significantly low [the Last Glacial Maximum (26~18 ka)]—gradually increasing [the Last Deglaciation and Early Holocene (18~8 ka)]—generally high [the Middle Holocene (8~2 ka)]—gradually decreasing [the Late Holocene (2~0 ka)]. Based on comparative analysis, we found that the regional effective moisture is controlled by the variability of solar insolation and ice volume in the Northern Hemisphere during the Last Glacial Maximum and Holocene, this further supports the view that environmental changes in the northern monsoonal margin of China are driven by high and low latitudes.