The research on marine biogeochemical cycles of copper （Cu） and zinc （Zn） and their isotopes is now active due to their roles as essential micronutrients for marine phytoplankton and their use as tracers of various physical， geological， and chemical processes in oceans. Notably， Cu and Zn are selected as key research elements in the international GEOTRACES program. Here， the research achievements and advances of marine Cu and Zn isotopes in recent years are reviewed. This includes： \mathrm{①} The vertical distribution characteristics of dissolved Cu and Zn isotopic compositions （δ⁶⁵Cu and δ⁶⁶Zn） in the marine water columns could be influenced by different ocean processes such as biological uptake， particle scavenging and complexation with organic ligands because these processes lead to the fractionation of Cu and Zn isotopes； \mathrm{②} The research on Cu and Zn isotopic compositions and their influxes and outfluxes of major marine sources and sinks has become more and more mature， but there are still potential sources and sinks of Cu and Zn that have not been found； \mathrm{③} Cu and Zn are extremely sensitive to changes in marine climate and environment， so Cu and Zn isotopes are often used to trace paleo-ocean climate and environment change. In the future， more studies are suggested to focus on optimizing the analysis methods of Cu isotopic compositions， exploring the potential sources and sinks of modern marine Cu and Zn cycles and Cu and Zn isotope fractionation mechanisms of marine biogenic carbonates. Breakthroughs are expected to be achieved in the applications of Cu and Zn isotopes to tracing carbon cycle， paleoclimate evolutions and marine environmental pollution.