Ecosystem services refer to the benefits that humans obtain from natural ecosystems. Landscape pattern is closely related to ecosystem processes/functions. Understanding the quantitative relationship between landscape pattern and ecosystem services in the context of climate change is an important way to improve the ability of a region/landscape to provide ecosystem services. This article reviewed the progress and existing problems in the research field of ecosystem service measurement, mutual relationship and optimal management. This article emphasized that the accurate measurement of the amount of ecosystem services is the basis of valuing it, and the constraint line approach has great potential in portraying the nonlinear relationship and threshold characteristics of ecosystem services. It is necessary to start from the integrity of human-environment coupling system to develop a new generation of earth system models and optimize regional ecosystem services on this basis, which is a landscape sustainability science approach to achieve the goal of regional sustainable development.