The construction of the Yangtze River Economic Belt is one of the major strategic initiatives to promote the sustained and steady growth of China's economy at current and the new normal stages. Comprehensive enhancing the governance levels of various natural disaster risks in the Yangtze River Economic Belt is the basic guarantee for promoting the implementation of the development strategy. Based on the multi-hazard integrated risk theory, the main disaster risks of the core cities (Shanghai, Wuhan, and Chongqing) of the Yangtze River Economic Belt and the major risk-earthquake disaster chain were systematically analyzed. The status and existing problems of multi-hazard integrated risk governance in the Yangtze River Economic Belt were expounded in this paper. The main problems include: Insufficient understanding of multi-hazard integrated risk formation mechanism; low level of safety fortification; Imperfect regional coordination and linkage mechanism; and insufficient role of insurance and reinsurance in risk transfer. Finally, the overall promotion strategies were proposed, including establishing multi-hazard integrated risk identification mechanism and governance capability evaluation system; comprehensive improving the fortification level of multi-hazard integrated risk prevention; establishing multi-hazard and multi-party linkage disaster monitoring and early warning systems; strengthening major disaster risk management and evacuation facilities construction; accelerating the construction of catastrophe insurance systems based on multi-hazard risks. This will provide a theoretical reference for major disaster risks studies in the Yangtze River Economic Belt.