The Antarctic and the Arctic regions play a key role in global sea level change and carbon cycle, and reserve key information of the Cenozoic transition from a green-house to an ice-house Earth. They have become hot spots in earth science studies. The geological drilling projects in both polar regions (e.g., DSDP/ODP/IODP/ICDP) have achieved remarkable successes, which have freshened the knowledge of global environmental and climatic evolution. Along with the Cenozoic global cooling, the timing of glaciation was almost synchronous on both the Antarctic and the Arctic. Accompanied with the Antarctic ice sheet build-up and increased terrestrial weathering, the enhanced formation of Antarctic Bottom Water exerts significant impact on global ocean circulation. The volume of unstable West Antarctic Ice Sheet fluctuates during glacial-interglacial periods showing 40 ka obliquity cycles, its volume significantly reduced or collapsed during several peak interglacials or long warm intervals. The Southern Ocean plays a significant role modulating atmospheric CO₂ concentration, global deep water circulation and nutrient distribution, productivity at different time scales. Sea level responses to the waxing and waning of polar ice sheets at different time intervals were tested, which provide valuable clue for predicting future sea level changes. The upcoming IODP drilling projects on polar regions will keep focusing on the high latitude ice sheet development, Southern Ocean paleoceanographic evolution, land-ocean linkages in the Arctic, and the impacts on the global climate, which will provide important boundary conditions for predicting global future climate evolution.