As the largest ecosystems of the earth, marine ecosystem provides many types of ecosystem service to human. More than 60% of the global population lives the coastal area. A healthy ocean is critical to our economy, health and way of life. However, with rapid population growth and densely inhabited coastal areas, our dependence on marine resources is greater than ever. The overuse and mismanagement of ecosystem services have placed great pressure on marine systems, thereby threatening the future of marine ecosystems, and the services they provide. With anthropogenic pressures increasing in coastal cities, adopting ecosystem-based management frameworks that minimize impacts on marine environments while allowing for sustainable development is critical. Marine Ecosystem-Based Management seeks to manage marine resources in ways that protect ecosystem health while providing the ecosystem services needed by people. Rather than focusing solely on a single species or resource, MEBM incorporates science and balances the demands of user groups in a manner that produces management strategies that are more likely to be sustainable than traditional approaches. The definition, principles and framework were discussed in this paper based on the summary of literature, and two examples were introduced. Last, some suggestions were put forward to marine ecosystem management for ocean ecosystem and for healthy coastal resources sustainable utilization.