The exploitation of (ultra) low airspace resource has become an important component of optimizing the utilization of airspace and has received worldwide attention. It is the major form for UAV activity, which reveals great socioeconomic prospects. Firstly, the background of exploiting (ultra) low airspace resource and challenge for UAV activities were analyzed in regional areas. Then, legal rights for UAV activities and routes design in overseas and domestic research were reviewed. Second, the forms of regional rules for UAV activities in (ultra) low airspace were summarized, which included height-density rule, coverage area rule and isolation area of rule. Third, based on the air network of UAV(s) and aiming at the demand of aerial lanes for different requirements, the development from the method of 3D city model to the Cost-to-go was prospected. The findings are as follows: UAV activities’ aerial lanes design includes high-density as general rules and coverage area rule, isolation area rule as special rules. On the basis of 3D city model, improved method of Cost-to-go is applied to the choice of the optimal aerial lanes; based on ground buildings and residents’ actual conditions in regional area, the rules and methods are good for the (ultra) low airspace resources development and better solve the problem of UAV activities coordination. Furthermore, the rules and methods play an important role even in the implementation of the national airspace system.