In this study, using an independently developed diagenetic physical modeling system, we conducted a series of diagenesis physical modeling experiments to simulate reservoir physical property of the Jurassic coarse sandstone from Dibei in Kuqa depression. These experiments reproduced the geological process of early, long-term, shallow burial and subsequent rapid, deep burial, and late tectonic uplift. As the gradual increasing of the simulated temperature, pressure, depth and the continuous strengthening of the compaction, intragranular irregular cracks appeared in quartz, and secondary dissolution could be more easily discovered in feldspar; Porosity, pore throat and K, Na, Ca, Al, Si, Ti, Mn in diagenetic fluid all showed significant evolution and regularity; Calcite, quartz, I/S mixed layer and chlorite were commonly found in modeling samples. At the depth of 3 000~6 500 m, accompanied by strong dissolution, pore diameter and throat diameter reached the maximum, and calcite cementation and quartz overgrowth also increased quickly. At the tectonic uplift stage of 5 000~4 500 m, under the influence of temperature and pressure relief, sandstone porosity began to rebound, and feldspar and rock debris were obviously dissolved under the acidic water from hydrocarbon charging. The formation of effective reservoirs in Western China’s oil and gas basins can be deeply influenced by the factors of dissolution, the process of early, long-term, shallow burial and subsequent rapid, deep burial, and late tectonic uplift, lateral extrusion and cracks induced by tectonic action.