Climate change is considered as the biggest global health threat of the 21^st century. The increasing adverse health effects of climate change has been a public concern worldwide. In order to develop the specific health response strategies, a key research project, "Climate change and human health: Risk assessments, early signals and response strategies", was approved by the National Key R & D Program of China in May 2018. This project will integrate researchers from multidisciplinary background, such as public health, medicine, meteorological sciences, disaster management, to address the following scientific questions: ①The impact of climate change on population health and its regional heterogeneity; ②The underlying mechanisms and pathways of how climate change and extreme events impact on health; ③Capture of the early signals of climate system anomalies which may lead to regional health risks; ④The comprehensive health risk assessments and development of coping strategies for tackling climate change. This project will improve our understanding of climate change and health and help policy maker to develop national and local responses to climate change in China.