A brief introduction to the Fifth Session of Global Platform for Disaster Risk Reduction, which was held in Cancun, Mexico, organized by United Nations International Strategy for Disaster Reduction (UN/ISDR) and hosted by the Government of Mexico from 22 May to 26 May 2017, was firstly provided. Combined with “Sendai Framework for Disaster Risk Reduction 2015-2030”, “Transforming our world: the 2030 Agenda for Sustainable Development”, and related work on natural disaster risk reduction at global, regional, country and local scales, some hot-topics and prospects of global platform for disaster risk reduction were put forward. Some findings were concluded, consisting of understanding disaster risk, disaster risk governance, building and enhancing resilience to disasters, coherence between the Sendai Framework, the 2030 Agenda for Sustainable Development and Climate Change Adaptation (CCA). Implementing the Disaster Risk Reduction (DRR) through cross-sectoral collaboration, removing barriers and promoting public-private cooperation in DRR and other types of partnership among multi-stakeholders will become the main force pattern of DRR in the near future. Large-scale disaster risk governance caused by multi-hazards (disaster cluster), disaster chain and disaster compound will be the main trend in scientific research of DRR. Building regional disaster risk reduction platform (e.g. the Silk Road Economic Belt and the 21st-Century Maritime Silk Road) and sharing the technologies and information of disaster risk reduction will be the main contents of DRR practices. Building and optimization of institutional mechanisms on DRR will be the trend of DRR idea. Improving and enhancing the support to communities, vulnerable groups and locals on DRR will be the main trend in DRR achievements’ application and demonstration in China.