Based on the analysis of metallogenetic characteristics of the uranium deposits in Guyuan region, summarizes the regional prospecting symbol, Various geological anomalous information of the area is analyzed. With the spatial analysis function of GIS, extracte the 14 favorable factors include strata, structure, subvolcanic rock, hydrothermal, alteration, geochemical anomaly, aeromagnetic anomalies, etc. were extracted, and the analytic hierarchy process model was built. Finally, based on the analysis, favorable areas were predicted according to the ore formation probability values.The prediction showed two firstgrade metallogenetic targets, seven secondarygrade metallogenetic targets and five threegrade metallogenetic targets, which laid the foundation for further prospecting in Guyuan region.