The Neoproterozoic strata which mainly distributes in the periphery of the Tarim Block records lots of Tectonothermal events related to the assembly and breakup of the Rodinia Supercontinent, yet the positon of the Tarim Block in Rodinia and how the Tarim Blcok moved after the breakup of Rodinia remains controversial. Based on the collection and selection of the published paleomagnetic data and the paleomagnetism method, we obtain the paleolatitude and drift path from Neoproterozoic to early Paleozoic of the Tarim Block.Moreover, combined with our field work and the isotope chronology data of representative rocks such as A type granite, mafic dyke swarms, continental flood basalt and bimodal volcanic rocks in the Tarim’s periphery, we conclude that there was a strongly rifting event surrounding the Tarim Block during 830~700 Ma BP,which caused the Tarim Block breaking off the Rodinia Supercontinent. However, the separation was not complete, and the Tarim block joined the Gandwana Supercontinent along with Australia.Through comparing the variation of the paleolatitude of the Tarim Block and the Australia Plate, we conclude that their separation time was about 450 Ma BP. Then,  the Tarim Block drifted towards north, and joined the Laurentia Supercontinent in late Paleozoic. During the Neoproterozoic to early Paleozoic, the Tarim block, on the whole, presented a drift parh from high north latitude to south latitude, and had a rapid return process to north latitude in the Ordovician.