With the shallow natural gas exploration becoming difficult at present ,deep-seated natural gas exploration has become the hot issue. Tarim basin, which is situated in the western part of China, is the biggest sedimentary basin in China. The study result show that Tarim basin has three major better hydrocarbon source rocks, which are the Cambrian-Ordovician, Carboniferous-lower Permian and Triassic-Tertiary source rocks, and high efficiency gas reservoirs and seal rocks, forming five sets of regional associations of gas reservoir and capping bed. Therefore, the basin has better physical condition for deep-seated gas generation, storage and conservation. Based on the present condition of gas exploration, the authors point out  that Kuche depression, Northern uplift, Central uplift, Bachu uplift and South-western depression in Tarim basin has wider exploration prospect for deep seated gas.