In this paper, North-south Transect of Eastern China (NSTEC) is compartmentalized into 8 physical regions with the accumulative temperature as the index. Based on the 8 physical regions, cultivation rate, land output, city number, city land use degree, land use fragmentation and land use degree as indexes are adopted to build up the index system of Land Use and Cover Change (LUCC) pattern by considered land use structure and land use degree. Through data transforming between natural pixel and social economic pixel, this paper illustrates differences of LUCC on physical regions quantitatively, and analyzes LUCC pattern in NSTEC in order to offer some science evidences for LUCC pattern analysis and its driving force. Finally, we find that agriculture activities are the most important among the human activities, which are the strongest in the south warm zone and north sub-tropic zone, are lighter in the northern than southern.