Mantle fluids are the most active mediums for mass and heat transport in the Earth’s mantle. They play important roles in the enrichment and depletion of Earth’s mantle and the origin of mantle derived magmatic rock with different geochemical features and facilitating the recycle of crustal and mantle’s materials. The simulation of trace elements partitioning between mantle mineral and fluid is a useful tool to estimate the fluid composition in the Earth’s mantle and constrain the role of fluid phases during metasomatic processes in the upper mantle and characterize crust/mantle recycling processes and explain the origin of high strength element depletions in arc magmas. In this article we review the recent progresses in the experimental studies of fluid/ mantle mineral trace element partitioning and analyze the controlling factors for mantle mineral/fluid trace element partitioning and summarize the applications of partitioning coefficients obtained from the high pressure and high temperature measurement. Despite the advances in our understanding of fluid/mineral partitioning, specific shortcomings exists in the database. Future research will surely have a significanly impact on our understanding of deep seated fluid.