A number of the independent CBM-bearing systems are often superposed in coal-bearing strata with multiple coal seams, and the interference among the systems impedes severely the efficient drainage and depressurization of CBM wells. The key to solve this problem is to find out the differences of the hydrogeological conditions among the systems. Based on the data of hydrogeological exploration in the Hongmei Well Field, Zhina Coal Field, western Guizhou, we analyzed the hydrodynamic and hydrochemical conditions of different coal-bearing intervals in the Upper Permian coal-bearing strata, and extracted the valuable information relevant to CBM development, including the apparent reservoir pressure, pressure coefficient, drilling unit water inflow, permeability coefficient and influence radius. It is revealed that the hydrogeological condition of different coal-bearing intervals in the formation is significantly different each other, indicating the existence of the multiple superposed CBM-bearing systems in conformity with the third-order stratigraphic sequence framework. The evaluation factor of CBM development condition was further established with grey relational analysis. Based on the factor, the CBM development potentials of different coal-bearing intervals were discussed and vertical development order was designed conceptually. Results showed that the interval of the No.17~30 coal seams with the best condition should be prior for CBM development, then the interval of the No. 6~16 coal seams, and finally the interval of the No. 30 seam-formation bottom with the relatively poor condition.