The interaction between atmosphere, hydrosphere, cryosphere and biosphere of the Tibetan Plateau (TP) significantly affects not only climate pattern and climate change in local and surrounding area, but also the Asian monsoon process and the global atmospheric circulation. The study of the #cod#x0201c;Tibet Plateau climate system change and mechanism of its impact on East Asia#cod#x0201d;, a project of the National Key Scientific Research Program of China for Global Change Study, was initiated in September of 2010. It aimed at performing integrated research on the Tibetan Plateau climate system responding to global change and its impact on surrounding areas, collaborating on major scientific issues to achieve breakthrough in scientific research on the Tibet Plateau climate system change and mechanism of its impact on East Asia, proposing prospective strategy coping with abnormal climate change to reduce regional natural disaster losses. A simultaneous and coordinated experiment of airborne remote sensing and groundbased observation was carried out in TP for the first time. And a series of research results have been achieved in the past three years of project implementation. The results include determination of regional distributions and seasonal variations of land surface heat fluxes in whole TP region, behavior of the tropopause folding events over the west TP, definition of plateau monsoon and its association with general circulation anomalies, decrements of solar radiation and wind speed across China and TP area in recent decades and their possible causes, weaken trend of sensible heat source in the spring over TP and its impact on the Asian summer monsoon, and classification of land cover in high altitude region of Mount Qomolangma, etc.