This paper describes the current status and perspective for the hydrological modelling over the Tibetan Plateau (TP). Hydrological models, as primary tools to study hydrological processes, can provide theoretical and decision support for water resources management as well as disaster prevention and mitigation in river basins. As is known, the first-generation hydrological models are “lumped”, and the second-generation hydrological models are “distributed”. However, most of the above models mainly describe the “precipitation-to runoff” water transport processes (“hydrosphere”) without carefully addressing the special role of vegetation in the water and energy exchanges in the landatmosphere interactions (“biosphere-atmosphere”). Over the past decade, in the context of climate change, with the vibrant developments of atmospheric science and ecology, distributed hydrological models began to describe the biosphereatmosphere interactions by improving the water and energy cycle formulations between the land and atmosphere, as well as enhancing the descriptions of physiological processes of vegetation. Up to now, a comprehensive description of hydrosphere-biosphere-atmosphere interactions in river basins has been realized by the hydrological community. However, regarding TP with a large portion of cryosphere land cover, the detailed cryospheric processes are of essence to be further considered in the multi-sphere hydrological modeling over TP. This will largely contribute to studies of the interaction mechanism among the cryosphere and other spheres (hydrosphere /biosphere /atmosphere), and thus improve the predictive ability of the region’s water resources and water-related disasters.