The occurrence of fire events is closely related to climate change and vegetation changes. A systematic study of the spatial and temporal evolutionary patterns of Holocene fire activities enables a clearer comprehension of the association between fire activity mechanisms and regional climate and vegetation changes, and contributes to the prediction of future fire evolutionary trends simultaneously. In order to comprehend the fire evolution and potential driving factors in the surrounding areas of the Andaman Sea, charcoal analysis was conducted on core ADM-C1 in the southern Andaman Sea to reconstruct its Holocene fire record. Additionally, five other charcoal records were synthesized to reconstruct Holocene fire activities in the surrounding areas of the Andaman Sea in this study. Although the nature of the changes of ignition, fire weather, and vegetation composition varied from place to place, leading to regional and local variations in fire frequency, the changes of fire event frequency around the Andaman Sea were widely synchronized under broader climate change during the Holocene. The frequency of fire activity around the Andaman Sea during the Holocene was influenced by regional variations in vegetation and precipitation, and ultimately by changes in the intensity of the Indian Summer Monsoon. Compared to the last deglaciation, there was a decrease in the frequency of fire activities in the surrounding areas of the Andaman Sea during 12.0~9.0 ka BP period, reflecting a gradual increase in Indian Summer Monsoon precipitation and woody plant abundance within this region. During 9.0~5.0 ka BP period, regional fire activity was constrained by higher Indian summer monsoon precipitation and woody plants. After 5.0 ka BP, an increase in regional fire activity primarily reflected a decrease in Indian Summer Monsoon precipitation. Furthermore, the changes in El Ni?o-Southern Oscillation (ENSO) intensity, Indian Ocean Dipole (IOD) phase and the location of the Intertropical Convergence Zone (ITCZ) were related to fire activity frequency around Andaman Sea during the Holocene.