Cretaceous Oceanic Anoxic Events (OAEs) have recorded significant changes in the climatic and paleoceanographic states of the planet and represent major carbon cycle perturbations. In the past two decades, analytical techniques for stable metal isotopes, such as molybdenum, zinc, uranium, chromium, cadmium, and calcium isotopes, have been developed to study OAEs. By systematically summarizing the geochemical characteristics of molybdenum isotopes (δ⁹⁸Mo), zinc isotopes (δ⁶⁶Zn), and uranium isotopes (δ²³⁸U), and research advances on Cretaceous OAEs, we found that molybdenum isotopes mainly reflect the transformation between sulfide and non-sulfide in the regional marine environment during OAEs. Zinc isotopes can reflect different responses of regional marine environments to different processes, such as primary productivity, continental weathering, and sediment burial/decomposition. Uranium isotopes can be used to estimate the global extent of seafloor euxinia. The coupled global C-P-U cycle model can simulate the response mechanism of the global ocean to different processes, such as the formation of large igneous provinces, continental weathering, and biological activities. However, the cyclic fractionation mechanism of these isotopes in marine systems is still in progress, and most research has only focused on the deposition record of OAE2. In the future, it will be necessary to conduct more systematic research on OAEs.