Compound-specific D/H ratios of lipid biomarkers contain valuable environmental information. The δD values of biomarkers represented by long-chain alkenones， dinosterols， and fatty acids have been increasingly applied to reconstruct paleo-Sea-Surface Salinity （SSS）. However， studies over the past two decades have shown that the δD of marine algae biomarkers is sensitive to many factors， such as salinity， species， temperature， and light intensity. Here， we focused on the impact of SSS on the δD of marine algae lipids and summarized the relationships between lipid δD and salinity from culture experiments and field studies. Then， based on the successful reconstruction of paleo-salinity with lipid δD， we put forward the problems that need to be addressed when applying it as a paleo-SSS proxy. It is hoped tha t this study will help us better understand the application potential of lipid δD and provide more accurate and detailed information for δD research.