There occur huge amounts of lead，zinc and other metals hosted by a mixed clastic-carbonate sequence in the giant Jinding Zn-Pb Ore Field in western Yunnan Province， SW China. The discovered lead-zin core mineralization isobviously characterized by an epigenetic hydrothermal origin and the complexity of theore-hosted rocksand faults-controlling style. So far， the coupling mechanism amongst them is unclear. In thiscontribution， 3D spatial data analysis on the Fengzishan Zn-Pb deposit were used to constrain the ore mineralization architecture and its spatial distribution characteristics， and to infer the coupling controlling mechanism between the main hosting rocks and the ore-controlling structures. The results reveal that the approximate NS-trending thrust faults and EW-trending strike-slip faults exerted a first-order control on the migration and accumulation of the ore-forming fluids， and provided for prior pathways and precipitation space.The distribution of the lead and zinc mineralization centers for the main ore bodies are parallel with the probable EW-trending faults， and of typical with the heterogeneous and segmented enrichment. They are spatially associated and/or intergrowth with pyrite， celestite（-barite）and gypsum as well. Therefore， the ore-forming fluids from the Miocene Jinding Group（N₁ j）with a basinal brine in nature， have been driven and controlled bythe approximate NS-trending thrust faults and EW-trending strike-slip faults， and precipitated in the Upper of Sanhedong Formation（T₃s³）by episodic mixing of multiple fluids. In particular， the discovery of this couple controlling on the ore mineralization by the approximate NS-trending thrust faults and EW-trending strike-slip faults and ore-hosted rocks， can provide us for understanding deeply the ore-forming mechanism and some key guidance for the future prospecting and exploration of this ore deposits， including similar deposits.