China has a vast territory， and there are obvious regional differences in climate change. The comparative analysis of China's climate change on a regional scale is of great significance to the attribution study of China’s surface environmental change. Based on the observed data of 483 meteorological stations nationwide from 1960 to 2018， the trends of temperature， precipitation， potential evapotranspiration， and moisture index were analyzed in conjunction with natural regionalization. The results showed that the variations of climatic factors exhibited the obvious spatial heterogeneity. Temperature showed a significant rising trend， with the average warming rate of 0.278 ℃/10a. Spatially， the increasing magnitude in the northern region was greater than that in the southern region， and the Tibetan Plateau region was larger than the subtropical region in the same latitude. The annual fluctuation of temperature showed a decreasing trend， and passed the 0.05 confidence test. Precipitation tended to increase in the northwest and southeast regions， while a decreasing trend was detected in the vicinity of the northeast-southwest ecological transition region. Except for subtropical humid region and tropical humid region， the annual fluctuation of precipitation in other ecological regions tended to remain constant. At the national scale， both the potential evapotranspiration and the wetness index showed an increasing trend， and wetness index passed the 0.05 confidence test. The significant decreasing trend of wetness index was found in the west of subtropical region， while the significant increasing trend was examined in the east of subtropical region， northwest of northwest arid region and mid-temperate region. Overall， China had experienced a dramatic climate change characterized by warming and wetting in recent 59 years， especially in northwest arid region， Tibetan Plateau region， and mid-temperate humid/semi-humid region. The study of the trend climate change in China is helpful for analyzing the impact mechanism of surface environment and ecosystem， and predicting the future climate change risk， which will provide scientific basis for regional climate change adaption and ecological construction.