Greenland Ice Sheet is one of the two largest ice sheets on the planet. Under the background of climate warming, the melting of the Greenland ice sheet and its contribution to sea level rise has become an international hot issue. The whole melting of the Greenland ice sheet can cause the global sea level to rise by about 7.3 meters. However, the dynamic mechanism that affects the mass balance of ice sheet is still unclear and is the greatest uncertainty source for predicting the rise in sea level in the future. The National Key Research and Development Program of China “A Study of the Monitoring, Simulation and Climate Impact of Greenland Ice Sheet” conducts monitoring and simulation studies on the key processes of instability of the “ice sheet-outlet glacier-sea ice” system, and establishes a satellite-airborne-ground integrated observation system, supporting the numerical simulation and impact research of the ice sheet and its surrounding sea ice, laying the foundation for long-term monitoring and international cooperation in Greenland. This program will work to reduce the uncertainty of sea level change projections by improving the ice sheet dynamic model forced by the ice core records, reveal the driving mechanism of sea ice changes around the ice sheet, focusing on the Northwest Passage, evaluate and forecast the navigation window period. The results of the project will deepen the understanding of the changes and impacts of the Arctic cryosphere, serve the safe navigation and operation of the Northwest Passage, and provide scientific support for the comprehensive risk prevention of coastal zones in China.