The general circulation models are used to simulate hydrogen and oxygen stable isotope in precipitation, which can enhance our understanding of the migratory processes of water stable isotope in water cycle and remedy disadvantages of measured data in spatial and temporal discontinuity. We used ten GCM (General Circulation Models) simulated data including stable isotope water cycle, and analyzed the spatial distribution characteristics of oxygen stable isotope effect in global precipitation. Meanwhile, we compared different simulated results as well as simulated results and the GNIP (Global Network of Isotopes in Precipitation) actual monitoring results. Our main purposes were to evaluate the simulative validity of stable isotope atmospheric circulation and improve our understanding and cognition for stable isotopic effect in water cycle. The results indicated that isoGSM, ECHAM4, LMDZ4 and HadAM3 showed good performances in simulating δ¹⁸O. Expect HadAM3, other simulated conclusion of models had good performances in the aspect of simulate seasonal difference of δ¹⁸O in spatial distribution. The simulated results of isoGSM, GISS E-F, ECHAM4, GISS E-N and LMDZ4 matched monitoring results more in the aspect of simulating relationship between δ¹⁸O and air temperature in spatial distribution. LMDZ4, isoGSM, GISS E-F, ECHAM4 and MUGCM had stronger capacity in the aspect of simulating relationship between δ¹⁸O and precipitation in spatial distribution. GISS E-F, isoGSM and GISS E-N had more advantage of simulate global meteoric water line.