Global climate change featured with warming has created serious challenge to world sustainable development and human security. It has become an important consensus of the international society to assess global change risk at the global scale and carry out tailored governance and risk-based adaptation. National Key Research and Development Program “Study on global change population and economic system risk forming mechanism and assessment” aims at quantitatively predicting future global climate change and population and economic system exposure and vulnerability change, developing global change population and economic system risk assessment model based on complex system dynamics, synthesizing risk assessment model with proprietary intellectual property rights, assess global change population and economic system risk of the near and mid future at the global scale, and compiling the atlas of global change population and economic system risk. The outcomes intend to serve the participation of global risk governance and international climate negotiation, and to provide scientific support to the implementation of international disaster risk reduction strategy.