This study investigated the changes of high temperature events during important growing period of rice (graining filling to maturity) of 2021-2050 due to climate change. Future climate scenarios were HadGEM2-ES simulation with RCP2.6 and RCP8.5 emission pathways. Relationship between high temperature and yield change was established from historical weather and field observations during 1981-2009 period. The impacts of high temperatures on China’s rice production up to 2050 were assessed by applying deduced regression models to climate scenarios. Key messages drawn from this exercise include: ①High temperature event exhibited gradual increase from 2021 to 2050 under both RCP2.6 and RCP8.5 scenarios, characterized by increased number of high temperature days (HSD), rising accumulated temperature with Tmax greater than 35 ℃ (HDD), and increased lasting days of high temperature (CHD). The HSD and HDD increased substantially in double rice cropping system of South China, single rice cropping system of Yangtze River Basin and rice area of Northeast China. ②High temperature hotspot was located near the border between Hunan and Hubei during 1961-2000, and might move towards northeast in the period of 2021-2050. ③Except the Northeast, China’s rice production suffered most from increased HDD during grain filling to maturity, indicated by significant negative and linear relationship between yield and HDD, whereas rice in Northeast China was subject to the increase of SDD during grain filling to maturity, with a significant and quadratic relationship between the yield and SDD. ④Compared to the high temperature risks during 1961-1990, climate change would increase the risks in majority of the rice area, especially in Hubei and Anhui-the central portion of Yangtze River Basin rice area, Guangdong, Guangxi and Hainan-south China double rice area, and south part of Northeast China single rice area.