Seafloor polymetallic sulphides are a huge development prospect of seabed mineral resources after the discovery of the Fe-Mn nodules and Cobalt-rich crusts. Seafloor polymetallic sulphides are produced by seafloor hydrothermal activities, which are high rich in copper, lead, zinc, gold and silver and other metals. Seafloor polymetallic sulphides mainly distribute in the mid-ocean ridge areas which have huge potential economic value and good development prospect. Currently, the main research focuses on the distribution of seafloor hydrothermal, mineralization mechanism, formation mechanism, environmental effect and so on, and the study and prediction of regional sulfide resources at this stage have almost not been carried out. Base on the information collection of the domestic and foreign researches of seabed mineral resources and comprehensive analysis of the characteristics of seabed mineral resources, the seafloor polymetallic sulfides resources ore-controlling factors and prospecting criteria were summarized, and a seafloor polymetallic sulphides descriptive resource prospecting model was initially established. The North Atlantic ridge area was chosen as the first stage to make a study to carry out the seafloor polymetallic sulfides resource forecasting. The predicted results of the weights of evidence method showed that there was a great relationship between the distribution of seafloor polymetallic sulfides resources and the indicators such as the depth of seabed topography, geophysical features, seafloor spreading rate, sediment thickness, submarine volcano seismics. The predicted results had a good superimposed effect with the existing hydrothermal point. Forecasting methods and model are credible and operational. The work of sulfide resource prediction and evaluation has a good guidance.