All organisms are composed of the same major elements, which uptakes, incorporation and storage would affect the organism growth, reproduction and metabolism processes. Phosphorus (P) determined the amount of rRNA in many organisms, which would constrain consumer concentrations of ribosome and thus protein synthesis and growth rate. P content increase and thus decreased C: [P and N: P ratios in many biota have been hypothesized to reflect P-rich ribosomal RNA at different growth rates(the Growth Rate Hypothesis, GRH). The GRH denoted that the C:P and N:P homeostasis in zooplankton fed with low C: ]P and high P food would deviate and increase allocation to Prich RNA to meet the protein synthesis demands of rapid growth; otherwise, secondary production would decrease and reduce C assimilation and transfer efficiency which would strongly bear on the sequestration of C in ecosystems. This paper reviews the framework of GRH in zooplankton, which aims to enhance the insight for C cycling and sequestration in ecosystems and their future tendency.