Across the Asia-Pacific region, coastal areas are highly varied in the status of water, sediment, nutrient, and pollutant discharges from catchments. Such changes are mainly caused by extremely intense human activities in the catchment basins, ranging from construction of numerous dams to the large scale utilization of chemical fertilisers, and, to less extent, by climate and sea level changes. The nature of catchment-coast interactions means that changes of material fluxes will result in morphological, environmental, and ecosystem changes in the catchment areas, estuaries, and adjacent coastal waters. In order to improve management of regional development under the changed conditions of the catchment-coast system, it is proposed that research should: (1) define the various changes quantitatively, on the basis of in situ monitoring and measurements; (2) understand the basic processes and mechanisms that are responsible for the changes; (3) develop new methods and techniques for the prediction of future changes, in terms of both trends and magnitude of fluctuations; and (4) apply the findings obtained from these studies to future catchment-coast development and management practices. Recently, a workshop was organized by APN (Asian Pacific Network for Global Change Research) to discuss about future research topics for the region. Following the workshop, the author completed a document for suggestions of future research directions within the study area of “Catchment-Coast Interactions”. The present contribution is a short summary of the document.