The study of fluid rock interactions in sedimentary basin mainly deals with four problems: 1) the source and distribution of organic acids and anions,and their effects on mineral stability; 2) origin and evolution of formation water; 3) redox reactions between hydrocarbon and rock,and 4) factors to change reservoir wettability.The above research is to trace reservoir geochemical process by means of experimental geochemistry and petrology,geochemical modeling. The paper reviews advancements of the area,and prospects its future.