In the light of author' s work on uranium deposits located in or near S-type granite of South China, this paper has commented upon the former points of view on their geneses, and discussed the relation among ∑CO₂, the crustal extension and uranium metallogeny. Direct towards the problems in former genetic research on hydrothermal ore deposits, the paper finally suggests that it is necessary to make efforts to strenthen the study of mineralizer geochemistry of mineralization.