Using surface observation data of Dunhuang, Wuwei, Dingxi agricultural meteorological stations from 1981(1986) to 2005, where lie in the hyper-arid, arid, semi-arid areas in northwest of China respectively, the impacts and their regional diversities of climate change on spring wheat growth and yields were investigated. The results showed that in about last 20 years or so, the climate change patterns were diverse both spatially and temporally in these stations. The temperature had increased and precipitation had decreased at Wuwei and Dingxi stations, but both of them increased at Dunhuang station. The correlativity analysis also revealed that the dominant factor of influence on spring wheat growth was different. In this study, at Dunhuang, Wuwei, Dingxi stations, the dominant influence factors were ≥0 accumulated temperature, daily mean temperature, and precipitation respectively. On the other hand, the direction, degree and intensity of influence of the same climate factor on crop growth and yields were also distinct in different regions. Owing to climate change, the yields of spring wheat increased significantly by 8.8 g/(m²·a） at Dunhuang station. However, at Wuwei and Dingxi stations, it decreased by 0.3 g/(m²·a）, 5.5g/(m²·a）  respectively. These differences could be attributed mainly to the different local climate conditions, secondly to the dissimilar non-climatic factors such as cultivate, management (irrigation, fertilization, disease and pest controlling)etc. The growth and yields in different regions were formed by the joint influence both climatic and non-climatic factors.