Most of the permafrost regions are located in mid-latitude plateau regions in China， which are different from the permafrost regions around the Arctic Ocean， and the genesis mechanism， occurrence environment and basic characteristics of Natural Gas Hydrate （NGH） are more sophisticated. Qilian Mountain is verified as the only permafrost area in which the samples of NGH can be obtained through scientific drillings. In the past 10 years， with the support of Special Research Project of the Ministry of Natural Resources and the National Special Project of Gas Hydrate of China Geological Survey， the key technologies of NGH geochemical exploration have been successively carried out in the Qinghai-Tibet Plateau and the Mohe basin. The effective index and identification marks of NGH geochemical exploration are optimized， and the accumulation mechanism of NGH in permafrost area is discussed. The geochemical exploration model of NGH was developed， and the geochemical exploration technology system for NGH was preliminarily established， which shows the validity of exploration practice. The effectiveness of geochemical exploration technology system for NGH has been preliminarily tested and applied， which has a broad application prospect.