Taking the Taizihe River Basin located in Liaoning Province as a study area, we applied HBV hydrological model to simulate the hydrological process of this river basin with the support of observed daily precipitation, mean temperature, hydrological data in Xiaolinzi hydrologic station, and global digital elevation model data from SRTM3, land utilization types, etc. According to the simulation results of daily runoff, the possible impact of future climate change on runoff was analyzed through forcing HBV model by RegCM4.4 dynamic downscaled climatic data. The results show that HBV model performed generally well for daily simulation of the Taizihe River Basin with Nash Sutcliffe coefficient and deterministic coefficient being all over 0.60 in the calibration period and validation period, and the response of flooding to precipitation were simulated better. This indicates the HBV model can be successfully applied to the Taizihe River Basin. Mean temperature will increase obviously with persistent rising trend by RegCM4.4 model in 2021-2070 under RCP4.5 scenario. Annual precipitation and runoff depth are expected to reduce a bit. Compared with the baseline period (1986-2005), annual runoff depth will increase by 9.79%. At the same time, the runoff depth will increase significantly in summer and autumn. The variation of runoff quantile indicates that both peak extreme runoff and dry extreme runoff will increase to different degrees than that in the baseline period. In the future, the Taizihe River Basin will be likely to experience extreme flooding.