Strontium isotopic evolution of the Phanerozoic seawater is an emerging research field of the material cycle in the Earth’s outer-spheres. It is greatly significant for the research of the environmental change on the Earth’s surface during the geological history. The researches of the strontium isotopic evolution of the Phanerozoic seawater have gone through three stages: The early stage, the accumulated stage, and the integrated stage. In the early stage, the primitive evaluation of the diagenetic alteration and the low precision of the analytical instruments resulted in most strontium isotope data without stratigraphic significance. Most researches were only at the initially exploratory stage. In the accumulated stage, the gradually mature evaluation of the diagenetic alteration and higher precision of the analytical instruments made ongoing progress in the researches, especially the establishment and development of the high-resolution strontium isotopic evolution curves of the Cenozoic seawater had spawned a new interdisciplinary branch: Strontium isotope stratigraphy. In the integrated stage, the accumulated high-quality strontium isotope data had been integrated into some strontium isotope database of Phanerozoic seawater. These databases are becoming one of the effective tools to solve the problems in the stratigraphy, petrology, ore deposit, hydrology, and other related applications. Currently, many problems still have not been satisfactorily resolved in the researches of the strontium isotopic evolution of the Phanerozoic seawater, such as the preservation differences of the original seawater information in a sample, the age of uncertainty of samples, lower dating accuracy of more ancient samples, the materials and stratigraphic questions of the Cambrian samples, trace rubidium contamination of samples, the isotope fractionation between ⁸⁶Sr and ⁸⁸Sr, the interlaboratory bias, the uncertainty of the data fitting, etc. These problems are the difficulties to possess more practicability and applicability of strontium isotope stratigraphy. Based on the summary of the research progress, we attempted to systematically summarize the stages and differences of the researches of strontium isotopic composition of Phanerozoic seawater at different periods. We wish this paper offer some perspective to the researches of strontium isotopic composition of Phanerozoic seawater in future.