Based on the research of minerogenetic condition, ore-control factors, metallogenic geological environment and geological anomaly of polymetallic sulfide in Indian Ocean, the nine evaluation factors include water depth, structure, earthquake, gravity anomalies, magnetic anomalies, etc. were extracted and standardized. According to hierarchy analysis method, a structural model of four levels was designed. The comparison matrix was established to determinate thefactor weight. A set of perfectEvaluation methodology and indicator system was established. The results showed that the most favorable prospecting areas cover 58.33% of the research area and the more favorable prospecting areas cover 32.41% of the research area. This two areas are mainprospecting targets. This research findings provided a basis for lessening the target area in the future.