In the past few years, following the hypothesis of tectonically driven climate change, the uplift of Tibetan plateau receives increasing interest and is tightly connected with the rate of continental chemical weathering and the evolution of marine strontium isotope. This paper thoroughly and minutely discusses the influences of Tibet plateau uplift and the changes in the global environment and climate on marine Sr isotopic evolution and the possible factors influencing the evolution. It is an important approach to solve the problem of the evolution and sources of marine strontium isotope by combining the uplift of Tibetan plateau, the global climate change and the rate of continental chemical weathering. Research work in this field should be focused on the rules of global climate change and the tectonic evolution of Tibet plateau on the basis of the evolutionary history of marine strontium isotope.