Artificial hydrological circulation process, including four sub-system contributing to water withdrawal, water transfer, water saving, and water use, respectively, is presented. The relationship among subsystems is described. The objective of this paper is to provide sets of data related to artificial water circulation for the study of hydroecological processes in the middle reaches of the Heihe River Basin. The changes of sub-systems between the year of 2000 and that of 2010 are analyzed by investigating hydraulic engineering, water resources condition, crop pattern, and agricultural water management. The results show: ①hat artificial water circulation process is playing a role to control agricultural water allocation in time and space, and is an important part of hydrological circulation process of the middle reaches; ② that, in 2010, the number of water withdrawal gates decreases by 26 and channel water use efficiency increases by 3.6% as much as that in 2000; and ③ that there is considerable changes in water resources development and utilization from 2000 to 2010, including surface water withdrawal reduction of 1.05#cod#x000d7;109 m3, and groundwater exploitation increase of 1.64#cod#x000d7;109 m3. Finally, effects of artificial water cycle on natural hydrological circulation are analyzed from runoff, groundwater, and atmosphere water perspective.