The iron-oxide Cu-Au deposits is a class of loosely related ores that share a pool of common characteristics but no common genetic relationship, it has become one of the major targets of Cu-Au exploration industry over the last decade. This class of deposits is characterized by the abundance of iron oxide (magnetite or hematite) in the ores and the associated intensive regional sodic(-calcic) alteration. They may occur in Proterozoic intracraton or Phanerozoic continental margin volcanic arcs with nearby intrusive complex or evaporite. The spatially and temporally associated intrusive rocks are magnetite-series granitoids. Mineralization mainly occurs in second order echelon structures near the main regional structure. The mineralization of a number of deposits of this class were associated with certain types of host rocks, but the most were formed by the unmixing of H₂O-CO₂-salt fluid with very high salinities and the mineralization is commonly linked to potassic alteration. There is argument whether the fluids responsible for mineralization is a dominant magmatic source or controlled by host rocks. The main genetic models include “an evaporite source model”, “a fluid heating model” and “a magmatic hydrothermal model”. However, detailed fluid inclusion and stable isotope studies at several deposits have indicated a dominant magmatic component to the fluids responsible for mineralization. The sorts of relationships between magnetite, sulphides and Cu-Au mineralization in Fe-oxide Cu-Au systems should be considered in the geophysical exploration. To study this type of deposits will be helpful for the discovery of new Cu resources base in China.