The forming and evolution of Qinghai Tibet plateau is an important research field, which is concerned by geologists all over the world and has very great effect on topography, rive systems, monsoon in Asia and the changes of climate and oceanic chemical composition in the world. However, because of lacking quantitative researches, some of key problems haven’t been solved. The appearance of mass balance offers a new method to solve these problems. In this article, the principle of mass balance is introduced, then application is illustrated with examples of basins in Tibet plateau, East China, surrounding Indo China and the Indian Plate. Some problems of using the method are discussed in detail, which would be the main research points in the future.