Hexi region of Gansu Province acts as an important role to be regarded as “developed poles” and “trailbreaker” in the implementary process of the great developmental strategy in western China. In this paper, the strategic thinking of ecological reconstruction and economic sustainable development are put out, the strategies are as follows: actualizing “great ecology” strategy with the ecological reconstruction to be regarded as the cut in point of economic sustainable development. Actualizing “great saving water” strategy with the furthest saving water and transmitting water in the small fields. Actualizing “great capital” strategy based on exploitation resources advantages to rely on the high new technique and market mechanism. Actualizing “great regulation” strategy by pushing industrialization, agriculture development and structure converting. Actualizing “great currency” strategy by constructing environment of greatly developing invest and opening. Based on these, the final objective is to construct Hexi region into a “green corridor” with economic sustainable development, people life level increasing markedly and eco environment improving gradually.