The dramatically increasing occurrence of harmful algal blooms (HABs) all over the world has attracted a great deal of attentions from researchers tying to mitigate the blooms. Some management strategies have been developed such as flocculation of microalgae with clay, biological agents. It is now fully convinced that blooms can be controlled and exorcised through microorganism,which has already become the hot issue. All we know is that actinomycete is a kind of microorganism producing much more bioactive substance relatively.Based on the varieties and high complexity of metabolites, actinomyces with algicidal features are playing more and more important role in HABs.It is possible that algicidal actinomyces will contribute to exploring new algicidal agents and mitigating the blooms.In this paper, the finding of algicidal actinomycetes and screening of bioactive substance, as well as new methods for controlling blooms are reviewed.Also, it focuses on the current development in the research of aigicidal actinomycetes and algicidal substances and refers to possibility and significance of algicidal actinomycetes maginiting blooms. At last,the paper prosoects the research  trendency and application of researching algicidal actinomycetes and relevant bioactive substances. This implies exploring and finding various  mechanisms will be a long period and and will provide a better understanding of close beneficial interactions between algae and actinomycetes in favor of the effect of these ingteractions on algal blooms.