Vent-distal Sedimentary-Exhalative（SEDEX）ore deposits are the main source of lead-zinc minerals worldwide，however，their genesis and diagnostic marks are yet controversial. Recently，some important discoveries have been made in the study of typical vent-distal SEDEX ore deposits in the world， including： \mathrm{①} Submarine exhalative sedimentation is not the unique way of mineralization， and laminated mineralization is not an exclusive diagnostic signature of the genesis of such deposits； \mathrm{②} Contrary to the traditional view given that vent-distal SEDEX deposits are generally formed in a closed，reduced and down-warped submarine sedimentary environment，the host rocks of these deposits can be formed in an open and oxidized sedimentary environment； \mathrm{③} Methane anaerobic oxidation and submarine hydrothermal alteration may be the main mechanisms for the formation of laminated and layered mineralization of this type of deposits. These understandings not only challenge the traditional genetic model of SEDEX deposits but also lead to the change of traditional prospecting and exploration evaluation criteria. Therefore，it is one of the urgent tasks to strengthen metallogenic research of this type of deposits learnt from the existing research experiences.