The Last Interglacial or Marine Isotope Stage (MIS) 5e, is of great interest because it serves as an analog for the Holocene. The climate change and duration during Marine isotope stage (MIS) 5e are considerably well understood for recent and future climate. Despite great interest in this subject over many years, a number of issues concerning the climate circumstances of MIS 5e are by no means resolved. We analyzed 35 published palaeoclimate records with reliable chronologies and robust proxies in typical region of the world to evaluate climate change during MIS 5e. These data indicate that: ① The duration of this warm phase is thought to range from (128±2) ka to (116±2) ka. The climate of MIS 5e was likely relatively stable with a number of abrupt, weak amplitude, cool and/or arid events. And the difference between regions is noticeable for the occurrence, amplitude, onset and duration of these events. For example, marine records from the North Atlantic indicate that the climate of MIS 5e was relatively stable, however the records from Norwegian sea show that the climate of MIS 5e had a significant changes at the beginning and cold event in the Mid-Eemian; The δ18O, δD and CH4 in the ice cores from Greenland and Antarctica imply that climate was relatively stable during the last interglacial period, while in Europe from the north to the south the duration of this phase became shorter and the intensity of climatic events became stronger. In addition, the climatic conditions of MIS 5e reconstructed by climate proxy from China are various and have the subject of some controversy. ②The global climate response to the insolation forcing would have been uniform on suborbital timescale. Nevertheless, as a result of regional sundry climatic forcing factors, global millennial-scale/century-scale climate oscillations were marked by significant local features during stage 5e. ③ Based on the better chronological controls, the estimation of climate parameters, the high-resolution climate records, and precise knowledge of the phase relationship between climate changes in global, the earlier depiction for climate circumstances and environment change during Marine Isotope Stage 5e should be refined and our understanding of the climate dynamics and mechanism and climate modelling should be improved.