The risk assessment is not only the one of the most effective soft measures in natural hazard prevention, but also is the base of hazard risk management. On account of the specificity of various elements at risk and debris flow mechanism, the theoretical system and technical procedure of debris flow quantitative risk assessment for buildings and roads were established in the mountaineous area of Southwest China, which included three sections: ①To represent debris flow hazard quantitatively using the intensity index IDF through FLO-2D simulation; ②To build debris flow physical vulnerability curve based on the loss exceedance-probability from Qipan gully debris flow case; ③To quantify the expected loss of the important elements at risk based on their database after setting the future debris flow scenarios. The case study of Yangling catchment indicated that the responding mechanism between elements at risk and debris flow physical mechanism was described quantitatively by this quantitative risk assessment system, which can contribute to the construction planning and prevention measure making in the southwestern mountainous area.