3D metallogenic prediction is an important method and frontier of mineral resources exploration in the world. This paper introduces a case study of 3D metallogenic prediction based on 3D geological-geophysical model in Tongling mineral district. The research contents,methods,and results are summarized as the following aspects: ①Based on 25 comprehensive interpretation profiles,established 3D geological model of the study area. Using 3D property inversion of gravity-magnetic data technology to obtain 3D physical characteristics,a 3D geological-geophysical model was established;②Combined with the previous research on the metallogenic theory,this paper summed up some favorable geological conditions for ore-controlling,and established the quantitative prediction model;③By using“cubic predicting model”prospecting method, delineated 15 predicted targets according to the value of information and geological condition. This research built the 3D geological-geophysical model successfully,and under the guidance of geological prospecting theory,quantitatively extract the favorable prospecting information based on different deposit types. This research extends the traditional regional metallogenic prediction method to 3D space,and it has important guiding significance for the old mine prospecting.